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Understanding How Skin Cells Hold the Key to Anti-Aging


Understanding How Skin Cells Hold the Key to Anti-Aging

Researchers at Newcastle University have made what is being called a breakthrough discovery in terms of anti-aging. Specifically, the mitochondrial complex II enzyme stops working as people age. This enzyme, found in the mitochondria of cells, is necessary for keeping skin plump and smooth. The discovery that the enzyme activity decreases with age may help in the development of more effective anti-aging treatments that counteract this decline. Medical experts and live-in caregivers in Prestige may find the following information beneficial in terms of senior care.

The study, published in the Journal of Investigative Dermatology, shows for the first time that within human skin, there is a specific decrease in the activity of this important metabolic enzyme as a byproduct of the aging process. Professor Birch-Machin, who led the study, described the enzyme as a hinge between the two ways a cell makes energy and a drop in its activity. This hinge causes a reduced bio-energy in aging skin. As bio-energy decreases, damaging skin radicals increase, which leads to increased fine lines, sagging, and wrinkles. This enzyme can now be used as a specific biomarker to develop and screen anti-aging treatments.

During the study, complex II activity was monitored in 27 donors ranging in age from six to 72. Samples were taken from areas of skin protected from sun exposure to see if there was a change in activity with increasing age.

Researchers determined that enzyme activity significantly dropped with age per unit of mitochondria in cells derived from lower or dermis layers of the skin instead of the upper or epidermis layers of the skin. This is due to the amount of enzyme protein declined and the decrease was only observed in cells that stopped multiplying. Further research is necessary to understand functional consequences of the declining enzyme activity and to establish a way to assess anti-aging treatments for human skin.

Along with aiding in the development of an effective anti-aging treatment, researchers hope the findings of the study lead to improved understanding of how organs age. The data may also help develop better drugs for age-related diseases.

This breakthrough could open many doors in terms of senior health and wellness. In the meantime, seniors have other resources to turn to. Orlando Prestige  Home Care is a leading provider of live-in and hourly home care that promotes longevity and wellbeing. Not only do our experienced caregivers offer housekeeping assistance to our clients, but they also help seniors maintain healthy diet, regular exercise, and social skills. Call a friendly Care Manager today at [phc_phone] to learn more about how your loved one can benefit from our care.

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Kimberly Miller, RN, is a proud Florida native with an unwavering commitment to elder care that spans an impressive 25 years. Her extensive journey through central Florida’s hospitals, nursing homes, assisted living facilities, and hospice companies has not only honed her understanding of disease processes but has also cultivated a profound expertise in navigating the intricate landscape of elder care. Kimberly’s dedication to delivering the highest quality of care to patients and their families is evident in every facet of her career.Armed with certifications as an assisted living administrator, Kimberly’s primary focus on customer service and her drive to address the holistic needs of individuals—mind, body, and soul—have led her to a resounding conclusion: home care is the future of personalized, high-quality care. Her conviction is rooted in the understanding that a combination of healthy nutrition, physical and mental exercise, and social engagement is directly linked to improved physical and mental well-being.The recent global pandemic has served as a poignant reminder of the limitations of institutional care, further strengthening Kimberly’s resolve. Motivated by a profound desire to make a meaningful difference, she has taken the helm at Prestige Home Care. Here, Kimberly is dedicated to providing a level of care that goes beyond industry standards—a level of care she would wholeheartedly entrust to her own family.